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Asthma or bronchial asthma is a disease which is characterized by airways narrowing. It happens because of some agents provoke the airways making them inflamed. This disorder gains more and more scope nowadays making asthma one of the most widespread disorder nowadays. The evidence has proved that the amount of asthma sufferers grows rapidly.
This 72-year-old man with longstanding chronic asthmatic bronchitis and Kaposis sarcoma, involving only the integument, was admitted on July 12,1982 for evaluation of a new pulmonary infiltrate. The patient had been on prednisone at varying dosages (5-20 mg) for two years, in addition to oral terbutaline, aminophylline, inhaled isoetharine, and chlorprom-pamide. One year previously, he…
Twin studies and studies of familial aggregation have demonstrated a significant genetic contribution to asthma. Estimates of the heritability of asthma in twin studies have ranged from 36 to 79%. To date, 15 groups have reported results of genome-wide linkage analysis for asthma and/or its intermediate phenotypes in 17 distinct populations. Several of these groups…
Asthma is a deteriorating disorder of airway obstruction. It is like you are crashing down when you realize you have no air for breathing further. Asthma is a widely spread disease which gain scope daily. As the the evidence we may see data showing the terrible results. One in eleven children have asthma. Yes, it…
We found that low therapeutic concentrations of theophylline significantly increased aerosol penetration in the lung of healthy subjects based on the finding of significantly lower mean skew with theophylline. Neither mucociliary clearance nor tracheal mucociliary transport rate was different between theophylline and placebo trials. When aerosol deposition is taken into consideration, the data suggest that…
Delivery of aerosolized bronchodilator agents through metered-dose inhalers (MDI) has enjoyed wide popularity because these devices are portable and convenient, require minimum time for administration, and have the potential for effecting rapid relief of bronchospasm. More recently, it has been shown that MDI-delivered corticosteroids may reduce oral corticosteroid requirements in asthmatic patients who are chronically…
When the above considerations are taken into account, it seems that for aerosol therapy we require as ideals: (1) aerosol MMAD <5 to minimize oropharyngeal deposition, (2) slow, steady inhalation, and (3) a period of breath-holding on completion of inhalation. These ideals are hard to achieve for metered-dose inhalers (MDIs), partly because of the nature…
The ihalation therapy has several well-established advantages over the oral and intravenous (IV) routes: (1) A small dose of drug can be used; a few hundred micrograms of inhaled (3-agonist may be as effective as a 10-mg oral dose. (2) There is a rapid onset of action; an inhaled bronchodilator is effective within 5 minutes…
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