Anthropometric characteristics, pulmonary function and blood gases data for normal subjects and the three functional classes of patients are presented in Table 1. Group mean values for age, weight and height were comparable with each group. In patients, the hemoglobin concentration was within normal range (160±20 g/L for men in the laboratory); this measurement was…
Data analysis Lactates kinetics: From the serial measurements of lactate concentrations during exercise, the La/VO2 relationship was analyzed for each subject as previously described . Briefly, an exponential function, La = a + bV°2 where a + 1 is the intercept on the y axis and b is a dimension-less parameter describing the steepness of…
Protocol Pulmonary function tests: Standard pulmonary function tests including spirometry, lung volumes and carbon monoxide diffusing capacity of the lungs (DLCO) were obtained at baseline according to previously described guidelines , and related to normal values of Knudson , Goldman and Becklake , and Cotes , respectively. Exercise test: After the insertion of an arterial…
Subjects Fifty-four consecutive patients with COPD evaluated at the exercise physiology laboratory of Hopital Laval, Ste-Foy, Quebe and in whom serial arterial lactate measurements could be obtained during exercise were included in this study. In each case the diagnosis of COPD was based on previous or current smoking history and pulmonary function tests showing moderate…
However, the prevalence of this phenomenon is difficult to evaluate, and it is commonly believed that, because of ventilatory limitation, the vast majority of patients with COPD are unable to exercise sufficiently to activate their skeletal muscles and, thereby, produce a significant amount of lactic acid . Even if the peak lactate concentration achieved during…
In normal subjects, the amount of blood lactate that accumulates during exercise is related to the intensity of exercise achieved and is a marker of the degree of muscle activation attained . Several authors have reported that a significant increase in blood lactate also occurs during exercise in patients with chronic obstructive pulmonary disease (COPD)…
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