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Leukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary Disease (7)

Leukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary Disease (7)Interleukins
Interleukin-8 was measured in unconcentrated BAL using a commercially available enzyme-linked immunosorbent assay kit (Research and Diagnostic Systems, Minneapolis). The detection limit of this assay is 18 pg/ml.
Statistical Analysis
Values for BAL LTB4, IL-8, PLA, and absolute neutrophil count are reported as mean± SEM. Differences between groups were evaluated using the Wilcoxon rank sum test; the Bonferroni correction for multiple comparisons was used where applicable. Significance was defined as a probability value less than 0.05. Bronchoalveolar lavage measurements were correlated with alveolar-arterial oxygen pressure difference P(A-a)0, and absolute neutrophil count using linear regression.
Results
Patients
BAL specimens from 34 HIV-infected patients and five normal volunteers were analyzed. Nineteen patients had P carinii pneumonia, ten had NIP (five with pulmonary symptoms prompting bronchoscopy and five asymptomatic patients who underwent bronchoscopy under an investigative protocol), and five were asymptomatic patients enrolled in the protocol mentioned above who had no pathologic diagnosis made. None of these patients died within 1 month of bronchoscopy. Clinical and laboratory data are presented in Table 1.

Table 1—Clinical Characteristics and Bronchoalveolar Lavage Measurements of Batients and Control Subjects

Patient Age, Sex RiO*, mm Hg P(A-a)Oe, mm Hg ltb4,pgfail IL-8,pg/ml PLA*,disintegrations/min Absolute Neutrophil Count, cells/ml
Normal volunteers
1 21 M nm nm 14 71 1,211 0
2 30 F nm nm 2 86 0 5,842
3 40 M nm nm 3 57 632 656
4 21 M nm nm 15 34 0 3,930
5 23 M nm nm 17 50 nm 0
Asymptomatic HIV-positive patients
6 40 M 87 22 4 nm 2,602 1,600
7 40 M 99% saturated! nm 30 119 9,480 6,900
8 41 M 80 31 36 252 3,444 620
9 29 M 82 34 12 205 1,585 0
10 55 M 95 19 17 962 1,470 5,100
NIP, asymptomatic
11 36 M 84 22 33 nm 1,213 1,660
12 32 M 85 24 62 1,616 14,708 48,750
13 24 M 117 2 37 364 7,642 16,800
14 29 M 74 37 69 nm nm 40,000
15 28 M 93 14 36 425 1,921 0
NIP, symptomatic
16 43 M 109 2 65 64 35,709 nm
17 28 M 68 48 122 2,216 23,064 360,000
18 37 M 78 38 24 1,317 4,694 800
19 43 M 88 27 22 nm 14,976 300
20 37 M 89 24 81 nm nm 0
P carinii pneumonia
21 33 M 114 9 6 255 11,734 3,600
22 33 M 94 27 6 784 41,561 0
23 59 M nm nm 10 59 802 160
24 29 M nm nm 17 491 46,364 15,600
25 31 M 96% saturated! nm 14 107 1,287 700
26 29 M 50 61 13 nm 615 nm
27 37 M 97 18 12 nm nm 0
28 51 M 86 29 16 866 3,943 nm
29 34 M 96 22 32 69 695 0
30 40 M 104 16 12 647 23,375 nm
31 35 M 90 25 15 384 15,363 nm
32 55 M 79 nm 9 1,176 42,062 6,300
33 42 M 78 34 20 278 9,029 5,700
34 33 M 93% saturated! nm 34 nm 53,539 3,240
35 25 M 98% saturated! nm 32 141 3,989 0
36 45 M nm nm 15 309 4,936 0
37 29 M 74 38 23 2,700 3,296 264,000
38 28 M 93 14 6 543 15,696 5,600
39 39 M nm nm 9 485 1,176 19,200

Category: Pulmonary disease

Tags: absolute neutrophil counts, bronchoalveolar lavage, Bronchoscopy, carinii pneumonia, hiv-positive patients

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