In 24 (77 percent) of 31 patients, positive serologic features were found: ANA in 21, ACA in six, and Anti-Scl antibodies in seven patients (Table 1).
Patients’ pulmonary (unction studies revealed varied abnormalities for several analyzed indices. The most frequent abnormality was the Deo reduction in 17 patients (55 percent). TLC and FVC were reduced in 11 (35 percent) and in 12 (39 percent) patients, respectively. MEF25 was reduced in seven (22.6 percent) and FEV! in 12 (39 percent) patients, while FEV/FVC was reduced only in one (3 percent) patient. RV and RV/TLC (>0.40) were elevated in 11 (35 percent) patients.
All the 31 control subjects showed normal FVC, TLC, Deo, Kco, and FEVj/FVC values. However, four (13 percent) control subjects had a reduction in MEF25 that was consistent with isolated SAD, while two of them also had elevated RV and RV/TLC levels. The number of patients with reduced MEF25 or elevated RY RV/TLC was not different from that of the control subjects with the corresponding abnormalities. FVC, FEVi, TLC, Deo, and Kco mean values in all patients were significantly lower compared with control subjects. However, no differences were observed between the patients and the controls in FEV1/FVC, MEF25, RV, and RV/TLC mean values, which are related, to large and small airways abnormalities (Table 2).
Table 1—Demographic Data and Clinical and Laboratory Findings in the 31 Fatients with Systemic Sclerosis
|Age, yr||51.5 ±13.4|
|Disease duration, yr||6.4±4.6|
|Pulmonary symptoms||13 (42)|
|Clinical findings||8 (26)|
|Roentgenologic findings||18 (58)|
|Positive serologic features||24 (77)|
Table 2—Pulmonary Function Tests tn the Fatients with Systemic Sclerosis and the Control Subjects (Mean±SD)
|FVC, % predicted||82.4 ±20.2||102.1 ±14.2|
|FEV,, % predicted||83.1 ±19.9||101.4 ±13.0|
|FEVj/FVC, X100||86.0 ±7.5||91.1 ±14.4|
|MEF25, % predicted||83.9 ±26.5||91.8 ±31.0|
|TLC, % predicted||84.8 ±17.4||98.1 ±12.2|
|KY % predicted||93.7 ±26.3||102.0 ±17|
|RV/TLC, X100||38.0 ±6.6||36.2 ±5.8|
|Deo, % predicted||75.3 ±20.9||103.6 ±19.3|
|Kco, % predicted||73.6 ±16.4||91.1 ±13.2|