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Asthma News - Part 32

Lactate kinetics during exercise in chronic obstructive pulmonary disease: PATIENTS AND METHODS (1)

Subjects Fifty-four consecutive patients with COPD evaluated at the exercise physiology laboratory of Hopital Laval, Ste-Foy, Quebe and in whom serial arterial lactate measurements could be obtained during exercise were included in this study. In each case the diagnosis of COPD was based on previous or current smoking history and pulmonary function tests showing moderate…

Lactate kinetics during exercise in chronic obstructive pulmonary disease: Introduction (2)

However, the prevalence of this phenomenon is difficult to evaluate, and it is commonly believed that, because of ventilatory limitation, the vast majority of patients with COPD are unable to exercise sufficiently to activate their skeletal muscles and, thereby, produce a significant amount of lactic acid . Even if the peak lactate concentration achieved during…

Lactate kinetics during exercise in chronic obstructive pulmonary disease: Introduction (1)

In normal subjects, the amount of blood lactate that accumulates during exercise is related to the intensity of exercise achieved and is a marker of the degree of muscle activation attained . Several authors have reported that a significant increase in blood lactate also occurs during exercise in patients with chronic obstructive pulmonary disease (COPD)…

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